UDK: 616-008.9-053.2-085.31

Comparative efficiency of hypotensive therary in children and teenagers with metabolic syndrome

V.V. Bekezin, L.V. Kozlova

Смоленская государственная медицинская академия

Abstract

25 children and teenagers aged 11–16 with arterial hypertension accompanied by metabolic syndrome who received enalapril or bisoprolol as part of their therapy were studied. Administration of bisoprolol to children with metabolic syndrome has the advantage of minimal sympathic influence, which was evident from normal ABP daily index and TMR and SMR values (Holter monitoring results) as well as a higher level of compliancy. Bisoprolol had no negative effect on corabohydrate or lipid metabolism. Enalapril therapy was followed by IMMLV decrease, which testifies to more pronounced organprotecting properties of the drug. A strict recording of initial heart rate or of the state of intracardiac conductivity was not required. Insulin resistance decrease which is the main pathogenetic link of metabolic syndrome was also noted.

Keywords

hypotensive therapy, children and teenagers, comparative study, bisoprolol, enalapril

Contacts

Бекезин Владимир Владимирович – ГОУВПО «Смоленская государственная медицинская академия», ученый секретарь ученого совета академии, к.м.н., доцент кафедры госпитальной педиатрии СГМА, bvvsmolensk@pochta.ru