UDK: 616.018.74-008.6:616.137.83/87-004.6-007.271

CORRELATION BETWEEN PROINFLAMMATORY MARKERS OF ENDOTHELIAL ACTIVATION AND FIBRINOLYSIS SYSTEMS IN PATIENTS WITH ATHEROSCLEROSIS OBLITERANS OF LOWER LIMBS BEFORE AND AFTER SURGERY

V. A. Lazarenko, E. A. Bobrovskaya, A. V. Mezentseva

Курский государственный медицинский университет, кафедра хирургических болезней ФПО

Abstract

The analysis the correlation between proinflammatory activation markers (homocysteine, oxidized lipoprotein of low density, sVCAM-1, Annexin V) and fibrinolytic activity (PAI-1, t-PA) was conducted in patients with arteriosclerosis obliterans of the lower extremities before and after surgery. The revealed correlations between inflammatory marker concentration and increased prothrombotic capacity at the systemic level and in the affected limb remained significant even after reconstructive surgery.

Keywords

atherosclerosis obliterans, reconstructive surgery, endothelial dysfunction, markers of inflammation and fibrinolysis

Contacts

Бобровская Елена Анатольевна — к.м.н., доцент кафедры хирургических болезней ФПО, Курский государственный медицинский университет, e-mail: eabobrovskaya@ yandex.ru