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Comparative research of antihypertensive action of cardos and losartan

I.N. Tyurenkov, A.V. Nazvanova, N.G. Chepurina

Кафедра фармакологии и биофармации ФУВ, лаборатория фармакологии сердечно-сосудистых средств НИИ фармакологии

Abstract

The revealed hypotensive effect of oral ultralow doses (ULD) of antibodies to receptor type 1 ATII (cardos) in spontaneously hypertensive rats is a good foundation for a new class of hypotensive drugs. The detected hypotensive effect of ULD antibodies to components of renin-angiotensin system (RAS) may be due to modulating impacts of antibodies on the RAS. A significant decrease in systolic arterial blood pressure (SABP) was found in rats receiving cardos. Lozartan decreased SABP by 25 % and kept stable during the period of observation. ULD antibodies to receptor type 1 ATII (cardos) decreased SABP by 10 %. This hypotensive effect is of great interest in regard to developing original medicinal preparations of a new generation.

Keywords

ultralow doses antibodies, cardos, lozartan, spontaneously hypertensive rats

Contacts

Тюренков Иван Николаевич – д.м.н., профессор, зав. кафедрой фармакологии и биофармации ФУВ ВолГМУ, fibfuv@vistcom.ru