UDK: 616.151.5:618.2+616.151.5:618.39

PERSISTENCE OF HUMAN PAPILLOMAVIRUS IN THE UTERINE CERVIX AND ALLELIC GENE POLYMORPHISM OF TOLL-LIKE RECEPTORS AND INTERFERON LAMBDA

T. S. Kiseleva1, O. P. Gumilevskaya2, U. B. Matohina3, K. P. Vakhaniya3

1Михайловская центральная районная больница, 2Военно-медицинская академия им. С.М. Кирова, центр клинической лабораторной диагностики, 3Волгоградский государственный медицинский университет, кафедра клинической лабораторной диагностики с курсом клиническо

Abstract

The inheritance of a specific combination of alleles of the genes of toll-like receptors and cytokines is believed to lead to effective immunity against the human papillomavirus; some combinations are associated with insufficient immunity and lead to persistence of the virus in the body. The women were examined for the presence of DNA HPV 16 and 18 types by PCR. Depending on the persistence of the virus, the women were divided into two groups and a comparative study was conducted based on the findings of cytological diagnosis of cervical smears for the purpose of early diagnosis of dysplastic changes and molecular genetic analysis of polymorphisms of Toll-like receptor genes (TLR 9 (T-1237C and A2848G), TLR 3 Phe-412 Leu) and cytokine IL28 rs8099917 T> G.

Keywords

human papillomavirus, polymorphism, Toll-like receptor, Pap smear.

Contacts

Киселева Татьяна Сергеевна – врач клинической лабораторной диагностики, Михайловская центральная районная больница, Волгоградская область, е-mail: sveklashka@rambler.ru