UDK: 618.714-022.1-085.254-092.9
G. M. Shamojan, A. I. Trofimenko, A. H. Kade, M. A. Dzhopua, M. A. Movsesjan
ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России, Краснодар, Россия
Study of the involution processes of the postpartum uterus and the development of it’s regulatory tools is of great importance for the clinic medicine. The purpose of our work was to study the effect of the drug «Dalargin» on the condition of the uterus in rats on the 7th day after childbirth. During the study 2 groups of animals were identified: group № 1 (n = 15) – control,intact female rats after the parturition; group № 2 (n = 15) – experimental, female rats received the drug «Dalargin» 1.1 mg / kg for 3 days after the parturition. According to the histological researches it can be seen that epithelization of the uterine horn in rats of both groups by the 7 days after the parturition is at the stage of completion. Female rats from group № 2 (received «Dalargin») showed that the thickness of the uterine horn wall was 9 % higher, the thickness of the myometrium was 12 % higher, the thickness of the single-layer prismatic epithelium layer was 31 % higher than in the control. A feature of rats received «Dalargin» is the restoration of a layer of mucus on the surface of the endometrium by 7 days after the parturition. Thus, the use of the drug «Dalargin» enhances the recovery of the endometrium of the uterus after the parturition and slows the turnover in the myometrium.
endometrium, myometrium, turnover in the rat uterus, Dalargin, opioid peptides
Трофименко Артем Иванович – к. м. н., ассистент кафедры общей и клинической патологической физиологии ФГБОУ ВО КубГМУ Минздрава России, e-mail: artemtrofimenko@mail.ru