UDK: 616.12-008.331.1:616.379-008.64
M. E. Statsenko, M. V. Derevyanchenko, M. N. Titarenko, S. V. Turkina
Волгоградский государственный медицинский университет, кафедра внутренних болезней педиатрического и стоматологического факультетов
Aim: to evaluate the features of the parameters of ambulatory central aortic pressure monitoring (CAP) in patients with arterial hypertension (AH) in combination with diabetes mellitus (DM) type 2. Materials and methods: 120 patients with stage II-III of AH aged from 40 to 65 years old were included into the research. The 1st (the main) group (n = 80) consisted of patients with AH and DM of type 2, the 2nd group (control) consisted of patients (n = 40) with «isolated» AH. The groups were comparable in terms of the main clinical and demographic characteristics. The parameters of CAP were determined using a multifunctional complex BPLab (Petr Telegin, Russia). Results: Pulse aortic pressure (PADao) was significantly higher in patients with AH and type 2 DM than in the group of patients with AH without type 2 DM (54,0 ± 10,1 vs 46,3 ± 6,7 mm Hg) mainly due to an increase in PADao during the day (52,2 ± 9,9 vs 48,1 ± 4,9 mm Hg, p < 0,05). The overall index of augmentation (IA) was statistically significantly higher in the main group of patients than in the control group (32,9 ± 7,3 vs 26,8 ± 13,7 mm Hg) due to an increase in IA overnight in patients with AH and type 2 DM in comparison with those with «isolated» AH (37,2 ± 9,8 vs 22,6 ± 10,7 mm Hg, p < 0,05). Conclusion: The more unfavorable parameters of the ambulatory profile of the CAD were noted in the group of patients with AH and type 2 DM, compared with the group of patients with «isolated» AH. It reflects the increase in rigidity of the main arteries. The obtained data testify the patients with AH and type 2 DM to a higher risk of cardiovascular complications than the patients with «isolated» AH. It is necessary to take into account the effect of drugs on the elasticity of the vascular wall when choosing antihypertensive therapy in persons with AH in combination with type 2 DM.
arterial hypertension, type 2 diabetes mellitus, index of augmentation, central aortic pressure.
Стаценко Михаил Евгеньевич – д. м. н., профессор, зав. кафедрой внутренних болезней педиатрического и стоматологического факультетов, Волгоградский государственный медицинский университет, e-mail: mestatsenko@rambler.ru