UDK: 615.015:615.262.1:616.72-002-085.262.1

INNOVATIVE THERAPY OF RHEUMATOID ARTHRITIS: ALGORITHMS AND TARGETS OF TREATMENT

A.R. Babaeva, E.V. Kalinina, P.A. Bakumov

ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения РФ, кафедра факультетской терапии, кафедра профессиональных болезней с курсом общей врачебной практики

Abstract

In this article innovative issues of rheumatoid arthritis (RA) treatment with disease-modifying anti-rheumatic drugs (DMARD) have been discussed. Updated national and international (EULAR 2016) recommendations for management of RA have been analyzed. It was pointed out that current approach rests on treat-to-target strategy and on early aggressive therapy with conventional synthetic drugs and/or biological agents. The brief review of available biologics approved for RA treatment has been presented. The novel class of target synthetic disease modifying drugs (ts-DMARD) was highlighted. Authors have presented theirs clinical experience data demonstrating efficacy and safety of novel ts-DMARD Tofacitinib, a Janus kinase inhibitor in RA treatment.

Keywords

rheumatoid arthritis, disease-modifying therapy.

Contacts

Бабаева Аида Руфатовна – д. м. н., профессор, зав. кафедрой факультетской терапии, Волгоградский государственный медицинский университет, e-mail: arbabaeva@list.ru