UDK: 612.1:575.22:616-005.8(470.345)
T.A. Degayeva, I.V. Sychev, L.N. Goncharova
ФГБОУ ВО «Национальный исследовательский Мордовский государственный университет им. Н.П. Огарева»
Myocardial infarction (MI) occupies one of the leading positions among the complications of the cardiovascular system.The process of atherothrombosis lies in the genesis of MI development. An important mechanism of thrombus development is the genetic determinancy of methylenetetrahydrofolate reductase (MTHFR) gene. The purpose of this work was to study of this gene genotypes carriage and to estimate its prognostic significance in the development of myocardial infarction in the indigenous population of the Republic of Mordovia, depending on nationality. 88 patients with Q MI (Russian patients n = 48, Mordvia-Moksha n = 40) and 100 healthy subjects (Russians n = 50 and Mordva-Moksha n = 50) have been examined. The average age of patients with Q MI was (58,8 ± 6,4) years. In patients with Q MI, the carriage of the TT genotype of the MTHFR gene has been detected in 41 % of cases, and in healthy individuals of this genotype it has not been revealed. In patients of Mordvian nationality (moksha), the carriage of the genotype TT of the MTHFR gene was more frequent (47,5 %) than in patient of Russian nationality (37,5 %), with OR for the Mordovian-Moksha patients equal to 11.40 (CI 1.38–94, 0) and for patients of Russian nationality with OR = 7,69 (CI 1.57–37.76). It reflects a more significant risk of carriage of the TT genotype in patients of Mordvian (moksha) nationality in terms of increased thrombus formation and MI development.
gene of methylenetetrahydrofolate reductase, myocardial infarction, nationality.
Гончарова Людмила Никитична – д. м. н., профессор кафедры факультетской терапии с курсами физиотерапии, лечебной физкультуры, Национальный исследовательский Мордовский государственный университет им. Н.П. Огарева, e-mail: glnsm@mail.ru