UDK: 615.32221
A.V. Voronkov1, M.P. Efremova1, A.D. Gerashchenko1, .P. Voronkov 2
1Пятигорский медико-фармацевтический институт – филиал ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, 2ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здрав
A study devoted to the study of the nootropic component of the actoprotective activity of compounds of natural origin after the physical exertion was carried out. The experiment was performed on mature male masculine Wistar lines, weighing 200–230 g. In the course of the experiment, it was found that the course administration of the metaprot drug compared to the correction of the resulting cognitive imbalance, which is reflected in the reduction in the time to reach the site by 61.6 % (p < 0,05) in the Morris Water Labyrinth Test (VLM) NK, and also exceeded the time to reach the site of the group receiving ATACL by 28,7 % (p < 0,05). Of all the naturally occurring compounds tested, ATACL substance has the most pronounced nootropic properties. Time to reach the site was higher relative to the ND group by 46,1 % (p < 0,05), (the number of non-rat rats was 10 % at that), in the «VLM» test. In the test «Conditional reflex of passive avoidance» (ADPI) against the background of the introduction of the substance ATACL, as well as the preparation of the metaprot compared, after physical exertion there was a decrease in the latent period, relative to the indicator of the NK group by 67,6 % (ATACL) (p < 0,05), and by 67,9 % (metaprot) (p < 0,05). Course introduction of ATACL and metaprot to rats promoted the improvement of behavioral reactions of animals in the «TEI» test.
physical activity, nootropics, actoprotectors, metaprot, fenotropil.
Геращенко Анастасия Дмитриевна – аспирант кафедры фармакологии с курсом клинической фармакологии, Пятигорский медико-фармацевтический институт – филиал ФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава России, e-mail: anastasia_ge