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THE ANXIOLYTIC POTENTIAL OF A NEW SERIES OF DIAZEPINOBENZIMIDAZOLE DERIVATIVES

A.A. Spasov1,2, L.N. Divaeva3, D.V. Mal tsev1,2, T.A. Kuzmenko3, A.S. Morkovnik3, M.V. Miroshnikov1, A.S. Taran1, E.A. Zolotova1

1ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра фармакологии и биоинформатики; 2ГБУ «Волгоградский медицинский научный центр», лаборатория экспериментальной фармакологии; 3ФГАОУ

Abstract

The article describes the study of anxiolytic activity of a new series of diazepinobenzimidazole derivatives having in their structure two preferential substructures – diazepine and benzimidazole. According to the results of the study, a new series of compounds has anxiolytic activity of varying severity, which may indicate a high prospect for further in-depth study of the neuropsychotropic potential of new compounds. The anxiolytic activity of the compound under the DAB-19 cipher, which is higher than the diazepam.

Keywords

diazepinobenzimidazoles, DAB-19, anxiolytic activity, myorelaxation.

Contacts

Мирошников Михаил Владимирович – аспирант кафедры фармакологии и биоинформатики, Волгоградский государственный медицинский университет, e-mail: mihailmiroshnikov@mail.ru