UDK: 615.214.22

ANХIOLYTICAL PROPERTIES OF COMPOUND RU-31

. . Sultanova1, D.S. Yakovlev1,2, D.V. Maltsev1,2, .V. Miroshnikov1, Y.V. orkovina1,2, V. . Anisimova3, A.S. Morkovnik3

1ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра фармакологии и биоинформатики; 2ГБУ «Волгоградский медицинский научный центр», лаборатория экспериментальной фармакологии; 3ФГАОУ

Abstract

Based on the known participation of serotonin receptors in the pathogenesis of the development of various anxiety disorders and the previously established ability of the compound of the azole series of RU-31 to inhibit the 5-HT2A-subtype of these receptors, it suggested that this compound might influence the behavioral activity. The study conducted the behavioral activity of animals under the action of RU-31 compound in the «Open field» test and studied the anxiolytic profile of this compound in the tests «Elevated plus maze», «The punishable taking of water by Vogel». According to the results of the study, we can talk about the ability of the RU-31 compound to reduce feelings of anxiety and fear.

Keywords

5-HT2A-antagonists, anxiolytic action.

Contacts

Султанова Кира Тимуровна – соискатель кафедры фармакологии и биоинформатики, Волгоградский государственный медицинский университет, e-mail: sultanova.pharma@gmail.com