Journal of VolgSMU
Quarterly scientific-practical journal

UDK: 577.29:615+612.64

POSTNATAL DEVELOPMENT OF RATS’ OFFSPRING FROM FEMALES GETTING NEUROGLUTAME DURING THEIR PREGNANCY

L.I. Bugaeva, T.D. Denisova, I.N. Tyurenkov, J.A. Mazanova, V.V. Bagmetova, E.B. Lavrova

НИИ фармакологии ФГБОУ ВО ВолгГМУ Минздрава России, г. Волгоград

Abstract

The two month long observation of offspring from female rats, which were getting neuroglutame in the dose of 650 mg/kg (25-fold therapeutic dose) from the 6th to the 20th day of pregnancy, showed the absence of changes in physical development.At the same time comparison of the tested rats’ offspring with the group of control ones showed effects: activation of body weight increase; surpassing of the terms of muscular strength maturation and opening of eyes, as well as formation of reflex of turning over in the free fall and cliff avoidance. Descent of testicles into the scrotum of the male rats and vagina opening of the female rats matched the physiological standard and did not differ from the control indices. According to the research results there was made a conclusion about the absence of damaging influence of neuroglutame in the dose of 650 mg/kg on the processes of organo- and fetogenesis registered in the postnatal period of the offspring’s development.

Keywords

antidepressant substance, neuroglutame, derivative of glutamic acid, experiments on the offspring of rats, preclinical research.

Contacts

Бугаева Любовь Ивановна – д. б. н., заместитель директора НИИ фармакологии ВолгГМУ, e-mail: li_bugaeva@mail.ru