UDK: 616.12-008.04-085.322
M. A. Bychenkova2, V.N. Perfilova1, G. M. Latypova2, V.A. Kataev2
1ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра фармакологии и биофармации ФУВ; 2ФГБОУ ВО «Башкирский государственный медицинский университет» Министерства здравоохранения Россий
Were studied endothelioprotective and antiaggregant properties of Primula veris L. solid herbal extract (PVSHE) in animals under experimental chronic heart failure (CHF) caused by isoproterenol administration in a dose of 2,5 mg / kg twice a day for 21 days. It was shown that in the control group of animals with CHF, the introduction of acetylcholine increased by 21,2 %, while the non-selective NO-synthase inhibitor L-NAME reduced the rate of blood flow in the carotid artery of rats by 27,5 %, which was less than the same values in the intact group: 45,2 % and -46,8 %, respectively (p < 0,05). The introduction of acetylcholine caused an increase in the rate of blood flow in the carotid artery in rats with CHF who received PVSHE at a dose of 30 mg / kg by 43,4 % and mildronate at a dose of 50 mg / kg – by 43,8 %, which was significantly higher than in animals of the control group (p < 0,05). The non-selective inhibitor of NO-synthase L-NAME reduced blood flow in the animals with CHF receiving study medications: -40,4 % and -39,5 % (p < 0,05), respectively. It was found that the rate and degree of aggregation of platelets was higher in rats with CHF than in intact animals (29,6 % / min versus 20,6 % / min and 27,3 % vs. 18,8 %, p < 0,05, respectively ). In rats with CHF receiving PVSHE, the rate of blood flow in the carotid artery was 20% / min, mildronate -23,2 % / min, the degree of aggregation was 19 % and 21,9 %, respectively, which was significantly lower in comparison with animals of the control group (p < 0,05). It was found that the level of von Willebrand factor (vW) was higher in animals with CHF than in the intact group by 91,1 % (p < 0.05) and significantly lower in animals with CHF who received PVSHE by 31,4 % (p < 0,05) and mildronate 21,2 % relative to the control group of rats (p < 0,05). The obtained data testify to the endothelioprotective and antiaggregant effect of the PVSHE comparable to the comparative preparation mildronate.
Primula veris L. solid herbal extract, endotheliocyte and antiaggregant effect, chronic heart failure.
Перфилова Валентина Николаевна – д. б. н., доцент, профессор кафедры фармакологии и биофармации, Волгоградский государственный медицинский университет, e-mail: vnperfilova@mail.ru