UDK: 616-002.5

THE RESULTS OF THE RESEARCH ACTIVITY OF SILVER NANOPARTICLES IN VITRO AND IN VIVO AGAINST DRUG- RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS

A.V. Zaharov1, A.L. Hohlov2

1Ярославская областная клиническая туберкулезная больница, отделение легочного туберкулеза; 2ФГБОУ ВО «Ярославский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра клинической фармакологии с курсом инстит

Abstract

The paper presents the results of experimental studies on the antitubercular activity of silver nanoparticles. In vitro experiments on 117 MBT strains with resistance to isoniazid and other drugs with preserved sensitivity to rifampin (group 1) and 108 ml of MBT strains (group 2), bactericidal action of nanoparticles was demonstrated in 48,1 and 41,7 % of cases, respectively. With the combined use of nanoparticles with isoniazide, similar indicators were 65,3 and 60,5 %, respectively (p < 0.05). In the model of experimental tuberculosis in BALB/C mice, the best survival and seeding rates of the pathogen from the lung tissue were also observed with the combined use of nanoparticles and isoniazide. The results obtained allow us to offer silver nanoparticles as adjuvants of chemotherapy for clinical trials.

Keywords

experimental tuberculosis, isoniazid, silver nanoparticles.

Contacts

Захаров Андрей Владимирович – к. м. н., зав. отделением государственного бюджетного учреждения здравоохранения Ярославской области «Областная клиническая туберкулезная больница», e-mail: Yrzahan@mail.ru