UDK: 615.071, 615.074, 615.011.4

METHODS OF PHARMACEUTICAL ANALYSIS OF BETAXOLOL HYDROCHLORIDE AND LATANOPROST

E.T. Zhilyakova, A.V. Agarina, O.O. Novikov, O.A. Kuzmicheva, D.K. Naplekov

ФГАОУ ВО «Белгородский государственный национальный исследовательский университет»

Abstract

The article provides an overview of the literature information and normative documentation describing the methods for the qualitative and quantitative determination of latanoprost, betaxolol hydrochloride, as well as the determination of latanoprost in combined ophthalmic dosage forms. It was revealed that the predominant method of identifying betaxolol hydrochloride is IR spectrophotometry and reaction to chlorides. For latanoprost, we apply the HPLC method and UV spectrophotometry. Both substances are quantitatively determined primarily by HPLC.

Keywords

latanoprost, betaxolol, pharmaceutical analysis, HPLC, TLC.

Contacts

Жилякова Елена Теодоровна – д. фарм. н., профессор, зав. кафедрой фармацевтической технологии, Медицинский институт Белгородского государственного национального исследовательского университета, e-mail: ezhilyakova@bsu.edu.ru