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CYTOKINE PROFILE IN PATIENTS WITH GOUTY ARTHRITIS IN COMBINATION WITH METABOLIC SYNDROME

K.V. Zhigulina, L.N. Shilova, A.V. Alexandrov, A.V. Sabanov

ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра госпитальной терапии, ВПТ с курсом клинической ревматологии ФУВ; ФГБНУ «Научно-исследовательский институт клинической и эксперимент

Abstract

There were 60 patients with reliable PA under observation (the diagnosis was established according to the classification criteria ACR / EULAR, 2015). All patients were divided into two groups: Group 1 – 40 patients with gout without MS signs, the second group included PA patients with signs of MS (75 % for women, 25 % for men). The average duration of the disease was (8,2 ± 3,5)years. In 25 patients there was a family history. Despite the differences in etiology and pathogenesis, the variety of clinical manifestations of rheumatic diseases (RH), the basis of most of them is chronic inflammation. A significant role in the formation of inflammation, which has a number of common immune mechanisms in some of the most common RH (rheumatoid arthritis,psoriatic arthritis, gout), belongs to cytokines, including tumor necrosis factor- (TNF-). It is with the hyperproduction of cytokines associated with an increased risk of atherosclerosis and associated with it vascular complications. Of particular importance is the metabolic syndrome, which is often observed in patients with gout. On the one hand, the metabolic syndrome is reversible, and on the other – significantly increases the risk of such socially significant diseases as type 2 diabetes and atherosclerosis.

Keywords

gout arthritis, metabolic syndrome, tumor necrosis-, interleukin-6, interleukin-10.

Contacts

Жигулина Кристина Владимировна – аспирант кафедры госпитальной терапии, ВПТ с курсом клинической ревматологии ФУВ, Волгоградский государственный медицинский университет, e-mail: kristya_87@inbox.ru