UDK: 615.015.11:577.322:615.015.42/.44::[616.379-008.64+616.894-0

DATABASE OF 3D MODELS OF RELEVANT PROTEIN-TARGETS OF THE RAGE-NF-KB SIGNSLING PATHWAY

P.M. Vassiliev1,2, L.R. Ianalieva1, A.N. Kochetkov1, V.V. Vorfolomeeva1, V. G. Klochkov1

ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, 1кафедра фармакологии и биоинформатики, 2НИИ фармакологии

Abstract

For 14 main nodes of the RAGE-NF-kB signaling pathway, 34 types of monofunctional proteins, subunits and isoforms have been identified that are related to the development of pathies in diabetes mellitus and Alzheimer’s disease. For human, 583 experimental X-ray and 1668 theoretical 3D models of these biotargets were found, a primary verification of their validity was performed. For the RAGE-NF-kB signal pathway, a database of 826 adequate 3D model of protein-targets of Homo sapiens has been formed.

Keywords

RAGE-NF-kB signaling pathway, protein-targets, 3D models, validation, database, systemic polyfunctional multitarget RAGE inhibitors, diabetes mellitus, Alzheimer’s disease.

Contacts

Васильев Павел Михайлович – д. б. н., с. н. с., профессор кафедры фармакологии и биоинформатики, Волгоградский государственный медицинский университет, e-mail: pvassiliev@mail.ru.