UDK: 617.735

INFLUENCE OF SHORT-TERM INSULIN THERAPY ON CONCENTRATION OF VEGF-A FACTOR IN INTRAOCULAR LIQUID IN CASE OF DIABETES ALLOXAN MODEL IN RATS

N.P. Pashtaev1, 2, 3, N.A. Pozdeyeva1, 2, I.V. Madyanov2, G.S. Shkolnik1, B.V. Gagloev1, D.S. Krestov2, A.A. Maksimov2

1Чебоксарский филиал ФГАУ НМИЦ МНТК «Микрохирургия глаза им. акад. С.Н. Федорова» Министерства здравоохранения Российской Федерации; 2ГАУ ЧР «Институт усовершенствования врачей»; 3ФГБУ ВПО «Чувашский государственный университет им. И.Н. Ульянова»

Abstract

Experiment was carried out on 80 mongrel rats in which diabetes was called forth by alloxan monohydrate injection. Experimental animals were divided into 2 groups. In the main group substitutional insulin therapy was begun, in control group animals didn’t receive special therapy. In 3 days of insulin therapy experimental animals of both the groups were excluded from investigation for intraocular liquids to be taken in which VEGF-A concentration was determined. We didn’t reveal reliable decrease of VEGF-A concentration in intraocular liquid between the groups.

Keywords

diabetes model, alloxan, daibetic retinopathy, VEGF-A, hyperglycemia, insulin.

Contacts

Паштаев Николай Петрович – д. м. н., профессор, директор Чебоксарского филиала ФГАУ НМИЦ «МНТК «Микрохирургия глаза» им. акад. С. Н. Федорова», e-mail: pr@mntkcheb.ru