UDK: 615.225'31
A.V. Voronkov1, N.B. Shabanova1, M.P. Voronkova2
1Пятигорский медико-фармацевтический институт – филиал ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации; 2ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здрав
The study of the decongestant activity of the new compound PIR-4 on the background of cerebral ischemia in rats was conducted. The experiment was performed on 50 male Wistar rats. Global cerebral ischemia was modeled by irreversible ligation of common carotid arteries. It is established that bilateral occlusion of the carotid arteries causes a decrease in the level of calcium ions in the blood (2,31 ± 0,06) mmol/l, metabolic lactic acidosis (11,4 ± 0,03) mmol/l, decrease of glucose consumption of brain tissue to (0,49 ± 0,34) mmol/l, which leads to swelling of the brain. Preventive administration of Vinpocetine, Cinnarizine and experimental compound PIR-4 allowed to correct the violations. So, against uses of the substance PIR-4 lactic acidosis significantly decreased to (3,64 ± 0,19) mmol/l, which is comparable to the drugs of comparison. The level of calcium in the group of animals treated with PIR-4 did not significantly increase by 9,1 % relative to the NK group of rats, glucose consumption statistically significantly increased to 15,33 %, the degree of hydration of brain tissues in the postischemic period significantly decreased by 1,97 %. The obtained results indicate the decongestant activity of the new pyrimidine-4-(1H)-a-PIR-4 derivative.
cerebral ischemia, rats, brain edema, lactatacidosis, pyrimidine derivatives.
Шабанова Наталья Борисовна – аспирант кафедры фармакологии с курсом клинической фармакологии ПМФИ – филиала ВолгГМУ, e-mail: Vahlushina@mail.ru