UDK: 616-006.6-091

DIAGNOSTIC INFORMATIVITY OF IMMUNOHISTOCHEMICAL BIOMARKERS IN CONDUCTING PRIVATIC PATHOLOGICAL AND ANATOMICAL RESEARCH OF PROSTATE CANCER

A.V. Smirnov1,2, D.V. Perlin1, M.R. Ekova1, D.YU. Gurov1, L.I. Aleksandrova1, V.S. Zamaraev1, R.P. Samusev1, L.N. Rogova1

1ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации; 2ГБУ «Волгоградский медицинский научный центр»

Abstract

The results of an in vivo pathoanatomical differential diagnosis of primary acinar adenocarcinoma of the prostate and benign lesions of the prostate gland were analyzed using a transrectal biopsy of the prostate gland using an optimized panel of antibodies to high-molecular cytokeratins (clone 34βE12), protein P63, AMACR, PSA and/or PSRA. The greatest diagnostic informativity of the basal cell differentiation marker of the columnar prostate epithelial cells was shown. The use of this set of biomarkers contributes to the establishment of a correct diagnosis and, in addition to the routine morphological examination of the biopsy material, can be recommended for carrying out an intravital pathologic anatomic differential diagnosis of prostate cancer.

Keywords

pathological and anatomical diagnosis, biopsy, prostate cancer, immunohistochemical research.

Contacts

Смирнов Алексей Владимирович – д. м. н., профессор, заведующий кафедрой патологической анатомии ВолгГМУ, e-mail: alexeysmirnov.volggmu@gmail.com