UDK: 576.385
. . Sladkova1, M.Yu. Skorkina1, N.I. Zhernakova2, V.N. Dmitriev3, E.V. Zhernakov4
1ФГАОУ ВО «Белгородский государственный национальный исследовательский университет», Медицинский институт, 1кафедра биохимии; 2кафедра семейной медицины; 3кафедра факультетской хирургии; 4кафедра акушерства и гинекологии
Using the model of the experimental hormone-dependent tumor of the ovaries of mature female rats, the morphofunctional properties of the blood constituents closely associated with neoplastic ovarian cells were studied. Using modern technologies of AFM scanning and confocal laser scanning microscopy, it is shown that the development of the tumor process in the body is accompanied by a decrease in viability and an increase in the number of dead lymphocytes. Functionally, the leading populations that respond to the development of the tumor process in the body are leukocytes, which are characterized by the reactions of spreading and smoothing out the microrelief of the surface. The development of the tumor process is accompanied by a change in the elasticity of blood cells, which allows early diagnosis of tumor transformations in various tissues and organs.
hormone-dependent ovarian tumor, blood shaped elements, atomic force microscopy, confocal laser scanning microscopy, microrelief, elasticity.
Сладкова Евгения Анатольевна – к. б. н., доцент кафедры биохимии медицинского института, Белгородский государственный национальный исследовательский университет, e-mail: sladkova@bsu.edu.ru