UDK: 616.89-008.441.33-092.4

DYNAMICS OF CONSUMPTION AND FORMATION OF THE PREFERENCE OF ALCOHOL IN RAT MALES AND FEMALES EXPOSED TO CHRONIC INTOXICATION OF 5 AND 10 % ETHANOL SOLUTIONS

V.V. Bagmetova2, N.S. Ganzikova1, I.V. Malyuzhenko1, A.A. Kolmakov3, L.E. Borodkina1, I.N. Tyurenkov1

ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации,1кафедра фармакологии и биофармации ФУВ; 2Научно-исследовательский институт фармакологии; 3кафедра оперативной хирургии и топографической ан

Abstract

In the conducted study of the dynamics of consumption and the formation of alcohol preference in male and female rats under conditions of chronic 25-week semi-forced alcohol intoxication with 5 and 10 % ethanol solutions (sweetened with 5 or 10 g sugar/100 ml solution, respectively), it was found that in the test «2-bottle sample» in the conditions of free choice between water and ethanol solution (5 %, without sweetener), carried out after 24-hour drinking deprivation on the 30, 60, 120 and 180th days of the study, animals of both sexes, who drank chronically 5 % ethanol, consumed more ethanol solution (g/kg) than those who drank 10 % ethanol. In males and females of rats who received chronically 5 % ethanol, the preference of alcohol to water (in % of the total fluid intake) was recorded from the end of 1 month of intoxication, in those who received 10 % ethanol from the end of 2 months of intoxication until the end of the study. After 2 months of intoxication in female rats that consumed chronically 5 % ethanol, after 4 months – 10 % ethanol, the consumption of ethanol solution was statistically significantly higher than that of males who drank ethanol of similar concentration. The level of alcohol preference in female rats that consumed chronically 5 and 10 % ethanol from the 60th day of the study was higher than that of the males who drank ethanol of the same concentration, on the 180th day of the study these differences smoothed out.

Keywords

ethanol, chronic alcohol intoxication, alcohol consumption and preference, sex differences, rats.

Contacts

Багметова Виктория Владимировна – д. м. н., с. н. с. лаборатории синтеза инновационных лекарственных средств НЦИЛС ВолгГМУ, e-mail: vvbagmetova@gmail.com