UDK: 615.244:615.31

RESEARCH THE INFLUENCE OF PARTIALLY HYDROGENATED PYRIDINES, DERIVATIVES OF CYANOTHIOACETAMIDE, ON BLOOD INDICATORS OF RATS WITH ACUTE TETRACYCLINE HEPATITIS

.Yu. Bibik1, B.S. Krivokolysko1, .P. Petlyuk3, A.V. Demenko1, K.A. Frolov1, 2, V.V. Docenko4, S.G. Krivokolysko1, 2

1ГУ ЛНР «Луганский государственный медицинский университет им. Святителя Луки», кафедра фундаментальной и клинической фармакологии, кафедра фармацевтической химии и фармакогнозии; 2ГОУ ВПО «Луганский национальный университет им. Владимира Даля», НИЛ «Химэ

Abstract

Currently, a focused search for new and safe hepatoprotective agents is highly relevant. An experimental study was conducted on 70 male rats after intragastric infiltration of tetracycline hydrochloride at a dose of 1000 mg/kg for 5 days.Screening researches of six partially hydrogenated pyridines, derivatives of cyanothioacetamide, on a model of acute tetracycline hepatitis at a dose of 2,5 mg/kg showed a high hepatoprotective and detoxifying activity in all compounds. They stabilize the level of biochemical blood parameters, keeping them at the normal level in terms of hepatotoxicity induced by the use of high dosages of tetracycline in vivo.

Keywords

tetracycline, partially hydrogenated pyridines, hepatitis, bilirubin, aminotransferases.

Contacts

Бибик Елена Юрьевна – д. м. н., профессор, ГУ ЛНР «Луганский государственный медицинский университет имени Святителя Луки», e-mail: helen_bibik@mail.ru