UDK: 616.72-002.772
E.V. Papichev, B.V. Zavodovskij, L.E. Sivordova, Yu.R. Ahverdyan, Yu.V. Polyakova
ФГБНУ «Научно-исследовательский институт клинической и экспериментальной ревматологии им. А.Б. Зборовского»
Purpose of the work: to study the correlation between fetuin-A (FA) and bone remodeling markers including bone mineral density (BMD) in patients with rheumatoid arthritis (RA). Materials and methods: we measured FA and bone remodeling markers above 110 patients with RA and 30 healthy controls. Results: patients were divided in two groups – with low and normal FA levels (23 vs 87). Group with lower FA had higher rate of osteoporosis (86,9 % vs 36,7 %; p < 0,001) and osteoporotic fractures (52,1 % vs 13,7 %; p < 0,001), lower BMD in LI-LIV (F = 18,6; p < 0,001), femur Neck (F = 27,6; p < 0,001) and femur Total (F = 23,7; p < 0,001), lower levels of 25-hydroxycholecalciferol (25-(OH)D) (F = 8,03; p = 0,005) and higher levels of beta cross laps (F = 5,88; p = 0,016). Conclusions: low levels of FA associates with lower BMD, higher rates of osteoporosis and osteoporotic fractures, lower levels of 25-(OH)D and higher levels of beta cross laps in patients with RA.
fetuin-A, bone metabolism, osteoporosis, 25-hydroxycolecalciferol, rheumatoid arthritis.
Заводовский Борис Валерьевич – д. м. н., профессор, зав. лабораторией методов лечения и профилактики заболеваний суставов, заместитель директора по научной работе в ФГБНУ «НИИ КиЭР им А.Б. Зборовского», e-mail: pebma@mail.ru.