UDK: 616.379-008.64:616.61-085.31

CONNECTION OF NESFATIN-1 LEVEL WITH THE COMPOSITE CONSTITUTION OF THE BODY AND MARKERS OF BONE EXCHANGE IN PATIENTS WITH RHEUMATOID ARTHRITIS

T.Z. Kvlividze1, Yu.V. Polyakova2, Yu.R. Ahverdyan2, L. . Sivordova2, B.V. Zavodovskij1,2, .A. Zagorodneva1, A.T. YAkovlev2

1ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации; 2ФГБНУ «Научно-исследовательский институт клинической и экспериментальной ревматологии им. А.Б. Зборовского»

Abstract

Nesfatin-1 (NF-1) is a new bioactive peptide with pleiotropic activity. There is information about its pro-inflammatory activity and effects on osteogenesis. A total of 110 patients with rheumatoid arthritis (RA) and 30 people in the control group were examined. In patients with RA, a significantly higher level of NF-1 is determined in comparison with the control group. No expected correlation of NF-1 level with body composition in RA patients was found. The interrelation between NF-1 and the bone matrix formation marker (P1NP) was revealed, which indicates a possible effect of NF-1 on the differentiation and function of osteoblasts.

Keywords

nesfatin-1, adipokines, rheumatoid arthritis, composite body composition, osteogenesis.

Contacts

Квливидзе Тамара Зурабовна – аспирант кафедры клинической лабораторной диагностики с курсом клинической лабораторной диагностики ФУВ, Волгоградский государственный медицинский университет, e-mail: tzady.ka@yandex.ru