UDK: 616.72-002.77: 615.355: 616-097

EVALUATION OF ANTIBODIES TO XANTHINE OXIDASE IN DIAGNOSIS OF RHEUMATOID ARTHRITIS

A. V. Alexandrov, S. G. Mnatsakanyan, I. Yu. Alekhina, M. A. Makhachev, L. N. Shilova, I. A. Zborovskaya

ГУ НИИ клинической и экспериментальной ревматологии РАМН, кафедра госпитальной терапии ВолГМУ

Abstract

A technique of immunoenzyme evaluation of antibodies (AB) to хanthine оxidase (XO) on the basis of immobilized magnetic sorbents, which may be used in clinical laboratories, was elaborated for the first time. AB to XO were revealed in sera of rheumatoid arthritis (RA) patients, their concentration correlated with the pathologic process activity. Evaluation of AB to XO may be used as complementary test in complex diagnostics in order to characterize the activity of pathologic process and clinical forms of RA.

Keywords

rheumatoid arthritis, antibodies, xanthine oxidase, immobilized magnetosorbents.

Contacts

Зборовская Ирина Александровна – д.м.н., профессор, зав. кафедрой госпитальной терапии ВолГМУ, complex@vistcom.ru