UDK: 616.5-002.525 616.5-004.1

CORRELATION OF ELASTIN AND ELASTASE ANTIBODIES IN PATIENTS WITH SYSTEMIC SCLERODERMA AND SYSTEMIC LUPUS ERYTHEMATOSUS WITH PATHOLOGY OF THE CARDIOVASCULAR SYSTEM

I.P. Gontar , O.A. Rusanova , O.I. Emel janova , A.N. Krasil nikov

¹ФГБНУ «Научно-исследовательский институт клинической и экспериментальной ревматологии им. А.Б. Зборовского»; ²ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации

Abstract

Objective: to study the effect of antitogenesis on elastin and elastase in patients with systemic scleroderma (SSD) and systemic lupus erythematosus (SLE) on the cardiovascular system. Research methods: 42 patients with a diagnosis of SSD and 65 patients with SLE were included in the study. The control group consisted of 30 healthy individuals. Antibodies (AB)to elastin and elastase were determined by the indirect enzyme immunoassay method. Results: in patients with SSD, compared with the control, a significant increase in the incidence of antibodies to elastase (52 %) and elastin (38 %) was revealed. In patients with a diagnosis of SLE, AB to elastin were detected in 41,5 %. Antibodies to elastase were detected in 78,5 %. Conclusions: among the patients examined by us, in 47 % of patients with SSD and 16 % of patients with SLE, there was a cardiovascular system lesion associated with an increase in the number of antibodies to elastin and elastase, which is a predictor of the development of cardiovascular pathology in systemic diseases.

Keywords

magnetic sorbent material, elastin, elastase, аntibodies, systemic scleroderma, systemic lupus erythematosus.

Contacts

Гонтарь Илья Петрович – д. м. н., профессор, заведующий лаборатории клинической иммунологии, Научно-исследовательский институт имени А.Б. Зборовского, e-mail: i.p.gontar@mail.ru