Journal of VolgSMU
Quarterly scientific-practical journal

UDK: 616-035.1+616-073.788


I.G. Khmelevskaya, N.S. Razinkova, O.G. Betz, A.V. Seryozhkina, T.A. Minenkova, S.G. Boeva

ФГБОУ ВО «Курский государственный медицинский университет» Министерства здравоохранения Российской Федерации


A significant proportion of all newborns are children who have undergone intrapartum asphyxia with the subsequent development of cerebral ischemia. This article presents the results of the effectiveness of therapeutic hypothermia in newborns with a clinical diagnosis of cerebral ischemia 2–3 degrees. Modern treatment technologies can significantly reduce the mortality rate among children who have suffered severe intrapartum asphyxia. In this regard, the development of measures aimed at preventing the disability of children who survived after severe or moderate asphyxia is of increasing relevance. Hypothermia has a pronounced neuroprotective effect. At the moment, it is considered as the main physical method of neuroprotective protection of the brain. Therapeutic hypothermia requires the mandatory tracking of the dynamics of changes in the brain activity of the newborn, which is clearly presented during long-term EEG monitoring with the presentation on the screen of trends of amplitude-integrated EEG (aEEG), compressed spectrum and other quantitative indicators of the CNS. aEEG trends during EEG amplitude changes in compressed form reflect the severity of hypoxic-ischemic disturbances, sleep patterns, identify convulsive activity and predict a neurological outcome in newborns. Based on the results of electroencephalograms, positive dynamics of the EEG pattern in newborns after the application of therapeutic hypothermia was revealed: the synchronism of the outbreaks of flashes was maintained, the alternation of sleep-wake cycles was clearly observed, and epileptiform activity was not registered.


therapeutic hypothermia, cerebral ischemia, electroencephalography, newborns.


Разинькова Наталья Сергеевна – к. м. н., доцент кафедры педиатрии, Курский государственный медицинский университет, e-mail: