UDK: 616.12-008.46-085:612.821.3

EFFECT OF THE NHE-1 INHIBITORS ZONIPORIDE AND VMA-1321 ON THE LEVEL OF LIPID PEROXIDATION PRODUCTS AND ENZYMES OF ANTIOXIDANT SISTEM IN MITOCHONDRIA OF ANIMALS WITH CHRONIC HEART FAILURE

Perfilova, N.A. Gurova, T.A. Popova, V.V. Vishnevskaja, A.A. Ozerov, M.V. Kustova, N.V. Ovsjankina

ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации

Abstract

Inhibitors of NHE-1 zoniporide (1 mg/kg intraperitoneally for 13 days) and VMA-1321 (0,92 mg/kg intraperitoneally for 13 days) in rats with chronic isoproterenol intoxication in myocardial mitochondria reduced the level of malonic dialdehyde (MDA) by 18 (p < 0,05) and 11 % (p < 0,05), respectively, and increased superoxide dismutase (SOD) activity by 87,5 (p < 0,05)and 38,1 %, respectively.

Keywords

experimental chronic heart failure (CHF), oxidative stress, malonic dialdehyde, superoxide dismutase, Na+/H+ exchanger inhibitors (NHE-1).

Contacts

Перфилова Валентина Николаевна – д. б. н., доцент, профессор кафедры фармакологии и биофармации ФУВ, Волгоградский государственный медицинский университет, e-mail: vnperfilova@volgmed.ru