UDK: 618.3-06-08:577.112.385.2
A.V. Jurakova1, T.I. Lokteva1, S.L. Kuznecov2, M.A. Zatolokina3, E.S. Zatolokina3, V.V. Gureev1
1ФГАОУ ВО «Белгородский государственный национальный исследовательский университет», кафедра фармакологии и клинической фармакологии; 2ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Ро
Objective. To study the efficiency of using carbamylated darbepoetin and asialiated erythropoetin at correction of morphological and functional violations occurring in preeclampsia in the experiment. Methods. The experiment was performed on 100 female white rats of Wistar strain weighing 250–300 g. Carbamylated darbepoetin (Pharmapark LLC) in a dose of 50 and 300 mg/kg was administered subcutaneously 1 time per each 7, 10, 13, 16, 19 days of pregnancy. Asialiated erythropoetin in doses of 0,4 and 2,4 mg/kg was also administered subcutaneously 1 time a day from the 10th to the 20th days of pregnancy. On the 21st day of pregnancy, functional tests and laboratory examination were conducted. Results. Administration of carbamylated darbepoetin and asialiated erythropoetin in animals causes the expressed correction of pathological changes in experimental ADMA-like preeclampsia with the highest effect in a higher dose of the test drug. There was a significant rise in systolic and diastolic blood pressure, respectively, the improvement of microcirculation in the placenta, restoration of endothelium NO-synthesis function, proteinuria reduction. Conclusion. The results of this study prove the future outlook of the use of erythropoietin derivatives for correction of morphological and functional changes in preeclampsia and substantiate the reasonability of further research in this direction.
carbamylated darbepoetin, asialiated erythropoetin, preeclampsia, endothelial dysfunction, rats, proteinuria, microcirculation.
Юракова Алеся Викторовна – аспирант кафедры фармакологии и клинической фармакологии, Белгородский государственный национальный исследовательский университет, e-mail: 1161779@bsu.edu.ru