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IMMUNOLOGICAL INDICATORS IN THE DYNAMICS OF PROTESIATION WITH ACRYLIC PROTESTS

E.A. Maylyan, V.A. Klyomin, A.A. Vorozhko

ГОО ВПО «Донецкий Национальный медицинский университет им. М. Горького» Министерства здравоохранения ДНР, кафедра ортопедической стоматологии

Abstract

Acrylic materials can cause denture stomatitis of allergic origin. The purpose of the work is to study the characteristics of immunological reactivity in patients in the dynamics of acrylic denture treatment. Materials and methods. A total of 54 patients aged 42 to 88 years were examined. Immunological parameters were determined before and 1 month after the installation of acrylic denture. Results. The development of stomatitis 1 month after the installation of acrylic dentures is combined with initially elevated (p < 0,05) concentrations of IL-4 and total IgE in the blood serum. In addition, after the denture installation in patients with clinical signs of stomatitis, increased concentrations of IgE class anti-acrylic antibodies are observed (p = 0,04), as well as the growth dynamics of TNF-α (p = 0,03) and IL-4 (p = 0,04) cytokines’ levels in the oral fluid. Conclusion. The results obtained should be taken into account in predicting the development of denture stomatitis in clinical practice.

Keywords

acrylic, stomatitis, immunological factors.

Contacts

Майлян Эдуард Апетнакович – д. м. н., доцент кафедры ортопедической стоматологии, Донецкий Национальный медицинский университет им. М. Горького, е-mail: mea095@yandex.ru