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THE EFFECT OF ACETYLCYSTEINE ON NEUROPSYCHIATRIC INDICATORS OF RATS AFTER ACUTE ETHANOL INTOXICATION

E.I. Morkovin1,2, N.A. Osadchenko1, L.P. Knyshova1,2, D.A. Bakulin1, D.V. Kurkin1,3

1ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Научный центр инновационных лекарственных средств; 2ГБУ «Волгоградский медицинский научный центр»; 3Межкафедральный центр отработки практи

Abstract

Alcohol hangover is a specific condition which is poorly understood, and agreed scientific assessments regarding the methods for its pharmacological correction are lacking. This work was to study the effects of acetylcysteine on behavior and neurological status of male rats injected intraperitoneally with 20% ethanol (3 g/kg), and, after waking up, received a single oral dose of acetylcysteine (1 g/kg) or an equivalent volume of physiological saline; animals from the negative control group received saline only. Acetylcysteine decreased neurological deficits and improved exploratory activity in ethanolinjected rats. Thus, acetylcysteine relieves post-toxic state in rats, received high doses of ethanol.

Keywords

ethanol, post-toxic state, hangover, acetylcysteine, rat, non-clinical study.

Contacts

Морковин Евгений Игоревич – к. м. н., доцент кафедры фундаментальной медицины и биологии, Волгоградский государственный медицинский университет, e-mail: e.i.morkovin@gmail.com