UDK: 616-092.6

ENDOMETRIAL RECEPTIVITY AND EXPRESSION OF APOPTOSIS AND PROLIFERATION FACTORS IN THE ENDOMETRIUM OF WOMEN WITH HYPERPLASIA AND INFERTILITY

A.A. Grishkina, G.N. Chistjakova, I.I. Remizova, O.A. Melkozerova

ФГБУ «Уральский научно-исследовательский институт охраны материнства и младенчества» Министерства здравоохранения Российской Федерации

Abstract

The role of various pathological processes that might affect the receptivity of the endometrium is actively discussed. In particular, the endometrial hyperplasia caused by dysregulation of proliferation and apoptosis should be highlighted. The aim of this study is to determine the features of apoptotic and proliferative activity in the glands and stroma of the endometrium, as well as its receptivity during the window of implantation in women with infertility and simple non-atypical hyperplasia. Material and methods. In this study endometrium were obtained from biopsies of women free of disease (n = 31) and patients with endometrial hyperplasia and infertility (n = 31) after that morphological and immunohistochemical examination were performed. Results. The endometrium, from women with endometrial hyperplasia during the implantation window, is characterized by decreasing of the area and height of pinopodia, the level of LIF expression by gland and stroma cells is almost halved, of bcl-2 is significantly increased in the stroma, and the expression of p53 and Ki67 decreased in the epithelium of the glands. Conclusion The revealed changes in the morphology of cells and their immunohistochemical profile indicate significant inhibition of endometrial receptivity. Overexpression of bcl-2 in the stroma and a significant decrease in cells with positive expression of p53 and Ki67 in the gland epithelium in women with endometrial hyperplastic processes may underlie reproductive dysfunction.

Keywords

infertility, endometrial hyperplasia, endometrial receptivity, pinopodia, apoptosis.

Contacts

Гришкина Анастасия Александровна – м. н. с., врач-патологоанатом отделения иммунологии, клинической микробиологии, патоморфологии и цитодиагностики, Уральский научно-исследовательский институт охраны материнства и младенчества, e-mail: xumukyc.ru@mail.ru