UDK: 615.825.1:616.12-008.16-092.9

ROLE OF POLYAMINES SYSTEM IN PATHOGENESIS AND TREATMENT OF REGENERATIVE AND PLASTIC HEART FAILU

D. P. Khloponin

Ростовский государственный медицинский университет

Abstract

Polyamines (putrescine, spermidine, & spermine) are associated with an ongoing myocardial injury in the failing heart. The cardioprotective effect of beta-blockers during heart failure treatment is partly explained by polyamines metabolism modulation. Cardioselective beta1-blocker nebivolol is shown to normalize the myocardial level of putrescine, spermidine & spermine, which are essentially disturbed in adriamycin-induced regenerative & plastic heart failure in rats.

Keywords

polyamines, nebivolol, beta-blocker, adriamycin, heart failure, apoptosis

Contacts

Ростовский государственный медицинский университет