UDK: 616.12-008.331.1-056.25-06:616.124.2

ASSESSMENT OF THE LINK BETWEEN PRO-INFLAMMATORY CYTOKINES AND STRUCTURAL AND FUNCTIONAL DISORDERS OF THE MYOCARDIUM IN METABOLIC SYNDROME

E.A. Bodrova, A.A. Tarasov, A.L. Emel janova, I.V. Lekareva, A.R. Babaeva

ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра факультетской терапии

Abstract

According to current data, chronic systemic inflammation plays an important role in the pathogenesis of obesity, metabolic syndrome (MS) and atherosclerosis. As you know, MS increases the risk of cardiovascular disease and is associated with more significant changes in the structure and function of the myocardium. Of particular interest is the study of the relationship between morphofunctional parameters of the heart and markers of systemic inflammation in MS. The aim of the study was to study the dependence of the content of proinflammatory cytokines TNF-α, IL-1, IL-6 and IL-17 on the presence and severity of MS, remodeling of the heart and blood vessels, as well as diastolic dysfunction of the left ventricle (LV). We examined 130 patients with MS and arterial hypertension (AH) and 36 patients with AH without MS. All patients underwent ultrasound of the heart and blood vessels to assess cardiovascular remodeling and left ventricular (LV) function. Along with this, the level of circulating pro-inflammatory cytokines (TNF-α, IL-1, IL-6, IL-17) was studied. The results demonstrate a significant excess of all the studied cytokines in patients with MS compared with the group of hypertension without MS. A more significant increase in the level of cytokines was in the group of patients with complete MS, as well as in violation of the geometry and function of the LV, especially with adverse types of LV remodeling and a more severe degree of impaired myocardial relaxation. The obtained results not only confirm the inflammatory concept of the pathogenesis of MS, but also demonstrate the contribution of systemic inflammation to the mechanism of LV remodeling and dysfunction. From a practical point of view, the studied cytokines can be considered as objective markers or predictors of cardiovascular remodeling and LV dysfunction in MS.

Keywords

metabolic syndrome, heart remodeling, diastolic dysfunction, cytokines.

Contacts

Бабаева Аида Руфатовна – д. м. н., профессор, зав. кафедрой факультетской терапии, Волгоградский государственный медицинский университет, e-mail: arbabaeva@list.ru