UDK: 615+577.29:615
L.I. Bugaeva, T.D. Denisova, I.N. Tyurenkov, Yu.A. Mazanova, N.M. Scherbakova, L.M. Ganicheva
ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации
In experiments on rats, it was found that a new derivative of glutamic acid (neuroglutam) when administered intragastrically at doses of 26 mg/kg (therapeutic dose) and 650 mg/kg (25-fold therapeutic dose) during organogenesis (6–16 days pregnancy) does not have an organo- and fetotoxic effect, recorded in the antenatal and postnatal periods of fetal development. In pregnant female rats, under the influence of neuroglutam, pre- and post-implantation death of fetuses decreased, and the fecundity and quality of antenatal development of the fetuses did not change. It was revealed that in offspring, from female rats receiving neuroglutam during organogenesis, the increase in body weight increased, the timing of opening the eyes, the formation of the pupil reflex, the avoidance of clipping caused by visual stimulus were ahead of time, and motor behavior was activated at 20 days of age. Moreover, in 1,5 and 2 month old rats, behavioral activity and mnestic reactions were at the level of the control group.
neuroglutam, experiments on pregnant rats females, antenatalny and post-natal development of posterity.
Бугаева Любовь Ивановна – д. б. н., зам. директора, зав. лабораторией токсикологии НЦИЛС с опытно-промышленным производством, Волгоградский государственный медицинский университет, e-mail: li_bugaeva@mail.ru