UDK: 611.08

THE POSSIBILITY OF USING THE BIOLOGICAL MODEL OF FRESHWATER FISH DANIO RERIO IN PRECLINICAL RESEARCH

A.V. Zub, V.L. Zagrebin, I.A. Dvoryashina, A.V. Terentev

ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра гистологии, эмбриологии, цитологии

Abstract

The article presents a literary review of domestic and foreign studies that reflect the possibility of using the biological model of Danio rerio (Zebrafish) in preclinical research. Data on the use of the toxicology Biomodel, determination of toxic and teratogenic effects of embryogenic substances, including certain medications, are presented. The use of zebrafish in modeling depression and stress, hypo- and hyperthyroidism, diabetes mellitus and in reproductive technologies is described. The proven effectiveness of the use of Danio rerio in preclinical studies and in modeling a number of human diseases is noted. The data of proteomic studies of the protein composition of cells are summarized zebrafish with the ability to determine the toxic effect at the molecular level.

Keywords

biological model, preclinical studies, Danio rerio, zebrafish, toxicology.

Contacts

Зуб Андрей Владимирович – ассистент кафедры гистологии, эмбриологии, цитологии, Волгоградский государственный медицинский университет, e-mail: Andrey_zub@inbox.ru