UDK: 616.928.8:578.833

ADVANCES IN THE STUDY OF DENGUE VIRUS: MODELS OF CELL LINES AND THE POSSIBILITY OF THEIR USE

E.V. Pimenova1,2, N.P. Khrapova1,2, .V. Zamarina1,2

1ФКУЗ «Волгоградский научно-исследовательский противочумный институт» Роспотребнадзора; 2ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации

Abstract

Recently the growth of dengue fever in both endemic and non-endemic regions of the disease was noticed. At present we don’t know enough about the mechanism of the disease and its individual manifestations, so we need to study the issues of etiology, pathogenesis. In this regard, a literature analysis was conducted. It was shown that cell lines are used for identification, detection and development strategies for the creation of candidate vaccines against the dengue virus. The cell lines are often not inferior in sensitivity and rationality to the method of infection of laboratory animals. The review summarizes the recent experimental data about the use of cell lines as target cells to study different aspects of the dengue virus, we also noted their advantages and disadvantages.

Keywords

diagnosis, cell lines, dengue fever, in vitro model, overview.

Contacts

Пименова Екатерина Владимировна – к. м. н., с. н. с. лаборатории иммунодиагностики ФКУЗ Волгоградский научно-исследовательский противочумный институт Роспотребнадзора, e-mail: ekaterina-304@mail.ru