UDK: 616.33:571.27
N.S. Iraklionova1, E.B. Belan1, S.V. Turkina2, A.M. Dotsenko3, E.L. Rudobaba1, A.A. Panina1, R.G. Myazin4
ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, 1кафедра иммунологии и аллергологии, 2кафедра внутренних болезней педиатрического и стоматологического факультетов, 3кафедра фундаментально
This article presents the results of the study of the immune status of the patients with inflammatory diseases of the upper gastrointestinal tract depending on the presence of H. pylori infection and allergic rhinitis. A total of 65 patients aged 18 to 40 years were examined. The lymphocyte immunophenotype by CD markers, the level of IgM, IgA, IgG, circulating immune complexes, IL-4, IL-10, total IgE in serum were determined in all patients. It was revealed that the number of mature CD3+ lymphocytes increased while the number of CD22+ cells decreased in patients with H. pylori infection. In addition, the level of total IgE, IL-4, IL-10 in serum was reduced in this group of patients. The results of the study indicate that the presence of H. pylori infection in patients with allergic rhinitis is associated with a slightly different nature of immunological reactivity compared with monopathology (allergic rhinitis) and H. pylori-independent inflammatory diseases of the upper gastrointestinal tract.
inflammatory diseases of the upper gastrointestinal tract, H. pylori, immune status.
Ираклионова Наталья Сергеевна – ассистент кафедры иммунологии и аллергологии, Волгоградский государственный медицинский университет, e-mail: ins2904@rambler.ru