UDK: 615:547.785.5:616.24-005.6-092.4

ANTITHROMBOTIC EFFECT OF A COMPOUND RU-1144 ON THE MODEL OF SYSTEMIC ARTERIAL THROMBOSIS

A.A. Spasov1, A.F. Kucheryavenko1, A.V. Smirnov1, K.A. Gaidukova1, V.S. Sirotenko1, N.G. Panshin1, O.N. Zhukovskaya2

1ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации; 2НИИ Физической и органической химии Южного федерального университета

Abstract

In this study, the antithrombotic activity of a new chemical compound of a benzimidazole derivative, which has a shielded phenolic substituent in its structure, under the laboratory code RU-1144 was studied, which exhibits high antiplatelet and antioxidant activity in vitro and in vivo tests. It was shown that the test sample has a pronounced antithrombotic effect and is superior in activity to the comparison drugs acetylsalicylic acid and clopidogrel in a model of cell thrombosis generated in mice.

Keywords

arterial thrombosis, platelet aggregation, lipid peroxidation, compound RU-1144, acetylsalicylic acid, clopidogrel.

Contacts

Гайдукова Ксения Андреевна – ассистент кафедры фармакологии и биоинформатики, Волгоградский государственный медицинский университет, e-mail: ksenijagajjdukva@rambler.ru