Journal of VolgSMU
Quarterly scientific-practical journal

UDK: 618+61:578.7

ANALYSIS OF THE CARRIER STRUCTURE OF THE HUMAN PAPILLOMA VIRUS IN PATIENTS WITH CERVICAL INTRAEPITELIAL NEOPLASIA OF A LIGHT DEGREE

L.V. Tkachenko, N.I. Sviridova, S.G. Shishimorova

ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра акушерства и гинекологии Института непрерывного медицинского и фармацевтического образования

Abstract

Objective. To study the carriage structure of human papillomavirus (HPV) in patients of reproductive age with mild cervical intraepithelial neoplasia. Subject and methods. A retrospective analysis of 396 medical records of patients of reproductive age with morphologically verified CIN I was performed. All patients underwent qualitative and quantitative genotyping for 21 types of HPV using the real-timepolymerase chain reaction. Results. It was found that among HPV high carcinogenic risk (HCR), the prevailing type: 16 type (47,5 %), 18 type (22,5 %), 31 type (16,7 %) and 51 type (16,9 %), and among low oncogenic – 6 type (8,3 %) and type 11 (6,1 %). When assessing the distribution of patients with CIN I by the number of simultaneously detected types of HPV, it was noted that in the vast majority of cases (55,8 %) one type was diagnosed, every fourth examined (25,5 %) found two types of HPV. At the same time, the largest proportion of women with morphologically confirmed CIN I, associated with two or more types of HPV, falls on the age group of 18–25 years. Conclusion. The revealed features of the frequency of occurrence of HPV HCR in patients of reproductive age of the Volgograd region should be taken into account when conducting cervical screening for the prevention of CIN.

Keywords

human papilloma virus, HPV carriage, cervical intraepithelial neoplasia, cervical screening.

Contacts

Свиридова Наталия Ивановна – д. м. н., доцент, профессор кафедры акушерства и гинекологии ИНМФО, Волгоградский государственный медицинский университет, e-mail: n.i.sviridova@yandex.ru