UDK: 615.017:616.079+615.2/.3.001.37
A.V. Voronkov, K.A. Miroshnichenko, D.I. Pozdnyakov, A.A. Potapova
Пятигорский медико-фармацевтический институт – филиал ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра фармакологии с курсом клинической фармакологии
Chronic traumatic encephalopathy (CTE) is a severe neurodegenerative disease that can affect people of all ages and professions. The aim of the study was to study the effects of drugs of different pharmacological groups on the course of CTE. Materials and methods. The pathology model was reproduced by dropping a 150 g load from a height of 0.5 m onto the parietal region of the rat skull for 7 days. Results. Based on the results of the experiment, the restoration of cognitive functions and a decrease in the concentration of markers of neurodegradation was established with the use of Cerepro, Panthogam, Hypoxene, Stimol, Phenibut. Conclusions: having analyzed the experimental data, it is possible to assume the presence of cerebroprotective activity in the studied drugs and the possibility of their use in the treatment of chronic traumatic encephalopathy.
chronic traumatic encephalopathy, nootropics, antihypoxants.
Воронков Андрей Владиславович – д. м. н., профессор, зав. кафедрой фармакологии с курсом клинической фармакологии, Пятигорский медико-фармацевтический институт – филиал ФГБОУ ВО «Волгоградский государственный медицинский университет», e-mail: prohor.77@ma