UDK: 618.3-06-08:577.112.385.2

INFLUENCE OF PEPTIDE IMITATING α-SPIRAL OF B ERYTHROPOETHIN ON THE DEVELOPMENT OF MORPHOFUNCTIONAL DISORDERS IN EXPERIMENTAL PRECLAMPPS

I.V. Golubev1, M.A. Zatolokina1, V.V. Gureev1, A.V. Polyanskaya1, A.V. Gureeva2, E.V. Avdeyeva2, E.S. Zatolokina2

1ФГАОУ ВО «Белгородский государственный национальный исследовательский университет»; 2ФГБОУ ВО «Курский государственный медицинский университет» Минздрава России

Abstract

Preeclampsia remains a formidable disease in the second half of pregnancy. Therefore, the search for new drugs for the treatment and prevention of preeclampsia is an urgent task of modern pharmacology. Materials and methods. The experiment was performed on female Wistar rats. The studied drugs were administered from 10 to 21 days of pregnancy. Functional tests were performed on the 21st day of pregnancy. Results. The use of a peptide that imitates erythropoietin α-helix B in experimental preeclampsia leads to a pronounced correction of pathological changes: blood pressure decreased, microcirculation in the placenta increased, and the morphological picture in the placenta improved. Resume. The results indicate the promise of the use of a peptide imitating α-helix B erythropoietin in experimental preeclampsia.

Keywords

peptide imitating α-helix of B erythropoietin, preeclampsia, endothelial dysfunction, rats, microcirculation.

Contacts

Голубев Иван Владимирович – соискатель кафедры фармакологии и клинической фармакологии, Белгородский государственный национальный исследовательский университет, e-mail: golubevvano@yandex.ru