UDK: 615.015:547.857.4

COMPARATIVE ANALYSIS OF ANTI-INFLAMMATORY AND ANALGETIC ACTIONS OF 1,3-DIAZINO-4 COMPOUNDS PYATd1 ACYCLIC PRECURSOR AND DAPSON

A.V. Voronkov1, S.A. Luzhnova2, I.P. Kodonidi2, S.A. Osychenko2, I.N. Dyakova2, O.N. Ignatiadi2, T.V. Chigikova 2

1 ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации; 2Пятигорский медико-фармацевтический институт – филиал ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здра

Abstract

In the experiment performed on 144 Wistar male rats, the anti-inflammatory activities of a new diazinone derivative under the code of PYATd1 and dapsone, were studied in the model of acute exudative and chronic proliferative inflammation. The analgetic activity was studied by mechanical irritation against the background of formalin sia. The results obtained indicate that the compound PYATd1 has pronounced anti-inflammatory and analgetic effects, superior to dapsone and comparable to ibuprofen, diclofenac and nimesulide.

Keywords

inflammation, felt granuloma, formalin edema, analgetic action, dapsone, compound PYATd1, ibuprofen, diclofenac, nimesulide.

Contacts

Воронков Андрей Владиславович – д. м. н., профессор, заместитель директора по науке НЦИЛС, Волгоградский государственный медицинский университет, e-mail:prohor.77@mail.ru