UDK: 616-06

ETIOPATHOGENETIC ASPECTS OF LIVER INJURY IN PATIENTS WITH COVID-19

V.I. Petrov1,4, A.V. Ponomareva1,5, I.V. Ivakhnenko2, O.V. Razvalyaeva3, B.A. Meshrqi6, V.I. Statsenko1

ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, 1кафедра клинической фармакологии и интенсивной терапии, 2кафедра амбулаторной и скорой медицинской помощи, 3кафедра внутренних болезней 4Н

Abstract

Infection caused by the new coronavirus SARS-CoV-2 initially associated with respiratory damage and the development of respiratory symptoms. However, it was subsequently shown that COVID-19 can be considered as a systemic inflammatory process with multiple organ damage. One of the most frequent extra pulmonary manifestations of SARS-CoV-2 infection is liver damage. Several factors of influence on the liver in COVID-19 are currently being considered: viral immunological damage, hypoxia, systemic inflammatory process, drug toxicity and progression of existing liver diseases. This review is devoted to the analysis of available data on the mechanisms and clinical manifestations of liver damage in a new coronavirus infection.

Keywords

COVID-19, hypoxic hepatitis, non-alcoholic fatty liver disease, cirrhosis.

Contacts

Пономарева Анжелика Викторовна – профессор кафедры клинической фармакологии и интенсивной терапии ВолгГМУ, e-mail: angelvr@yandex.ru