UDK: 616-018.2-053./575.1-07

MODERN PROBLEMS OF NISSUE DYSPLASIA IN CHILDREN PATHOGENESIS OF CONNECTIVE

N.S. Cherkasov1, Y. . Lutsenko1, M.Ya. Ledyaev3, T.N. Doronina1, A.V.Prakhov2, Ya.M. Ledyaev3

1ФГБОУ ВО «Астраханский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра госпитальной педиатрии с курсом последипломного образования; 2ФГБОУ ВО «Приволжский исследовательский медицинский университет» Мини

Abstract

Pathogenesis connective tissue dysplasia (CTD) is an important pediatric issue. CTD is characterized by polymorpfism of phenotypic and visceral signs. Pathogenetic aspect connected with disbalance of collagenic and non-collagenic proteins deserve special attention when children have non-hereditary forms of CTD. The role of elastin and laminin disbalance and the genome «major proteins» that participate in tissue structures’ formation remains an understudied issue.

Keywords

connective tissue dysplasia, pathogenesis, phenotypic and visceral signs of dysplasia, collagenic and non-collagenic proteins, elastin, laminin, children.

Contacts

Черкасов Николай Степанович – д. м. н., профессор кафедры госпитальной педиатрии с курсом ПО, Астраханский государственный медицинский университет, e-mail: kafedra1@mail.ru