UDK: 616.72-002.772: 616.61-07: 616-008

THE ROLE OF ANGIOPOIETIN-LIKE PROTEINS IN THE DEVELOPMENT OF RENAL DYSFUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS AND METABOLIC CHANGES

V.A. Aleksandrov1,2, L.N. Shilova1, A.V. Aleksandrov1,2

1ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра госпитальной терапии; 2Научно-исследовательский институт клинической и экспериментальной ревматологии имени А.Б. Зборовского

Abstract

The article is devoted to the assessment of the relationship between the serum concentrations of angiopoietin-like proteins of types 3 and 4 (ANGPTL 3 and 4) and the development of renal dysfunction in patients with rheumatoid arthritis (RA) with metabolic changes. We examined 158 patients with RA (91,8 % – women and 8,2 % – men) aged 21 to 80 years old with the average duration of diseases – 9 [4–15] years. Negative correlations of average strength between the indices of the estimated glomerular filtration rate (eGFR) according to the 2009 CKD-EPI formula and the level of ANGPTL 3 (r = –0,32, p < 0,001) and ANGPTL 4 (rS = –0,31, p < 0,001) were revealed. It was found that renal dysfunction and the presence of metabolic syndrome (R2 = 0,33) are the two factors which have a direct effect on the ANGPTL 4 concentration in RA patients’ serum. ANGPTL type 4 should be considered as a key factor linking the development of renal dysfunction and metabolic changes caused by rheumatoid inflammation.

Keywords

rheumatoid arthritis, angiopoietin-like proteins, glomerular filtration rate, metabolic syndrome.

Contacts

Александров Владислав Андреевич – ассистент кафедры госпитальной терапии, Волгоградский государственный медицинский университет, e-mail: alexandrow666@mail