UDK: 615.2.03

CUMULATIVE PROPERTIES OF THE NEW ANTI-MIGENOUS COMPOUND IN THE TABLET MEDICAL FORM

V.I. Kornilov1, D.S. Yakovlev1,2, V.V. Bagmetova1, L.I. Bugaeva1, A.A. Spasov1, A.Yu. Getmamenko1

1ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации; 2ГБУ «Волгоградский медицинский научный центр»

Abstract

Cumulative properties of 2-metoxifenil-imidazobenzimidazole derivative (RU-31) in tablet medical form (8 mg) were studied for development of new drug for migraine treatment. Four-week experiments were carried out on white rats of both sex, with intragastral administration of RU-31 water solution in the doses of 10 mg/kg and 100 mg/kg. On the 29th day the dose of tested compound equal to LD50 was administered to the animals. Due to the calculation of accumulation coefficient (more than 20 units) the tablet form of RU-31 shows the lack of cumulative properties.

Keywords

migraine, cumulation, 2-methoxyphenyl-imidazobenzimidazole derivative, RU-31.

Contacts

Яковлев Дмитрий Сергеевич – д. м. н., доцент кафедры фармакологии и биоинформатики, Волгоградский государственный медицинский университет, е-mail: dypharm@list.ru