UDK: 615.212.7

EFFECT OF ADJUVANT PREPARATIONS ON THE EXPRESSION OF ANALGETIC ACTIVITY OF MORPHIN IN SOMATOGENIC PAIN

Yu.V. Semenova, N.V. Eliseeva, A.A. Spasov

ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации

Abstract

Combination of traditional opioid with coanalgesics is recommended to reduce the dose of analgesics and the side effects as well as the relief of different pain severity. In this study was evaluated the effectiveness of different adjuvant drugs: haloperidol (0,45 mg/kg), metoclopramide (5 mg/kg), gabapentin (90 mg/kg), diazepam (1 mg/kg), midazolam (0,3 mg/kg), clonidine (1 mg/kg), atropine (2,7 mg/kg) with subanalgesic dose of morphine (1 mg/kg) in the somatogenic pain test (somatogenic pain was modelled with tail-flick). It was shown that the severity of the antinociceptive effect of morphine was significantly increased when combined with haloperidol, clonidine, gabapentin and metoclopramide; did not change when co-administered with midazolam and atropine; decreased when combined with diazepam.

Keywords

analgesic activity, somatogenic pain, tail flick, morphine, midazolam, diazepam, metoclopromide, atropine, haloperidol, clonidine, gabapentin.

Contacts

Семенова Юлия Викторовна – ассистент кафедры фармакологии и биоинформатики, Волгоградский государственный медицинский университет, e-mail: j_semenova_pharm@mail.ru