Journal of VolgSMU
Quarterly scientific-practical journal

UDK: 615.277.3;616-006.66

TARGETED DRUG DELIVERY SYSTEMS IN BREAST CANCER CHEMOTHERAPY

A.H. Al-Humairi 1, O.V. Ostrovsky 1, E.V. Zykova 1, D.L. Speransky 2

1 ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации 2 ГБУЗ «Волгоградский областной клинический онкологический диспансер»

Abstract

The article presents a review, systematizing the state and directions of development in the fabrication of targeted drug delivery systems in relation to the treatment of breast cancer. Drug delivery systems constructed on the basis of natural and artificial liposomes, nanoparticles of various nature, polymers, and dendrimer structures are consistently considered. For each class of platforms, information is provided on the features of the structure and functional properties of carriers, on successful examples of their use for the treatment of breast cancer at various stages of preclinical and clinical trials. The most probable directions to achieve a progress in the development of new systems for targeted delivery of antitumor drugs are shown.

Keywords

drug delivery systems, targeted therapy, nanomedicine, liposomes, nanoparticles, dendrimers, breast cancer.

Contacts

Хумаири Ахмед Хамид – аспирант кафедры теоретической биохимии с курсом клинической биохимии, Волгоградский государственный медицинский университет, e-mail: ahmed.h.mneahil@gmail.com